JuliaIa asked:


Imipramine, a tricyclic antidepressant WAS used to treat depression.
Iproniazid WAS used widely.
A warning label about the risk of suicidal thoughts WAS added to all antidepressant medications.

Kynysca asked:


From what I understand, it is typically indicated for pain, occassionally as a sleep aid. Also, that it isn’t even used for more than a couple weeks at a time. It is structurally similar to amitriptyline and imipramine, but never (from what I can see) prescribed for mood disorders. Why not? Perhaps I am missing something?
Thanx, Troy. Makes sense. I haven’t read anything reliable.

Wikipedia, at least, lists it as a tricyclic antidepressant:

http://en.wikipedia.org/wiki/Cyclobenzaprine

This research seems to list it as a TCA:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1540431

I can’t find anything “official”….
Troy, I have read “effects” of Cyclobenzaprine are comparable to a benzo. Could this drug be used as an anxiolytic? Is it, ever prescribed for this purpose?
Thanx, again, Troy. To be honest, I read the first paragraph of that research.

And, yeah, wiki is “off” a lot of the time.

I appreciate the edit, man :-).
I guess what I kinda got hooked up on is how cyclobenzaprine could be so structually similar to other TCA’s (even, despite it’s disparate class), yet not work similarly…

Brendan F asked:


I am on Imipramine (a Tricyclic antidepressant) and have noticed a distinct personality alteration. I am more relaxed, laugh more easily and am more focused but at the same time I have beconme dramatically less talkative, more insensitive, have a nasty/hostile attitude on ocassion and have been called “vain” and “self absorbed” for the first time in my life, multiple times. Has any one experianced similar reactions to antidepressants, tricyclics in particular, and what antidepressants do you take? I appreciate any feedback, even from those who have observed others personality change on antidepressants as well.

Tamerlane asked:


say for example: Imipramine.
I want to know why it is considered that Physostigamine and Flumazenil cannot be given? as it could convulsions ? I want to mechanism of the interactions and how it interfers with the role of TCA’s to reverse or delay the effects.